Abstract
The preparation of performance testing (PT) materials for environmental and radiobioassay applications involves the use of natural matrix materials containing the analyte of interest, the addition (spiking) of the analyte to a desired matrix (followed by blending for certain matrices) or a combination of the two. The distribution of the sample analyte concentration in a batch of PT samples will reflect the degree of heterogeneity of the analyte in the PT material and/or the reproducibility of the sample preparation process. Commercial and government implemented radioanalytical performance evaluation programs have a variety of acceptable performance criteria. The performance criteria should take into consideration many parameters related to the preparation of the PT materials including the within and between sample analyte heterogeneity, the accuracy of the quantification of an analyte in the PT material and to what "known" value will a laboratory's result be compared. This manuscript discusses how sample preparation parameters affect the successful participation in performance evaluation (PE) programs having an acceptance criteria established as a percent difference from a "known" value or in PE programs using other acceptance criteria, such as the guidance provided in ANSI N42.22 and N13.30.
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