Abstract
Diabetes is a real public health problem in the world. In Africa in general and in Cote d'Ivoire in particular, the management of diabetes is complicated by socio-economic difficulties. After the diagnosis of diabetes, its typing is carried out on the basis of clinical criteria. With the discovery of many subgroups of diabetes especially in Africa, the classification of diabetes is made difficult. This difficulty may raise questions about the adequacy of the therapeutic treatment of patients. The purpose of this study was to study mainly the contribution of basal C-peptidemia in the typing of diabetic subjects. The material concerned a population of 220 diabetics who carried out their peptide C assay and monitored at the Yopougon-ABIDJAN University and Hospital Center. Basal C-Peptidemia was assayed by competitive radio-immunoassay using the kit CIS –BIO Shering. The results revealed that the classification based on clinical signs was improved after the C-peptide assay. Indeed, after C-peptidemia, type 1 diabetics with low C-peptidemia (<0.5 ng/ml) and type 2 diabetics with normal C-peptidemia (0.5 ng/ml to 3 ng/ml). In conclusion, the determination of peptide C appears as an undeniable tool for better classification of diabetic patients. The results of C-peptidemia would direct the practitioner towards a more adequate treatment in the patients studied.
Highlights
Diabetes is a major public health problem in every country in the world
NB: The distribution of nosological forms was performed in the absence of the results of the basic C-peptidemia
In order to allow adequate treatment of diabetic patients, the Cpeptidemia assay has been proposed for a reliable approach to the residual insulin-secreting function of Langerhansian beta cells of the pancreas [4, 12, 16]
Summary
Much progress has been made in recent years in the area of classification and diagnosis of diabetes by WHO experts, but there are difficulties in classifying many subgroups of diabetics, especially in Africa This would be linked to forms peculiar to Africa which appear to be highly heterogeneous in terms of etiology and which the current criteria do not allow for grouping. To address these deficiencies, such as the inadequacy of the therapeutic choice and the difficulties of classification, the less widespread use of peptide C was proposed concomitantly with the usual dosages to improve the management of diabetes mellitus. It is produced in equimolar amounts to endogenous insulin but is excreted
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