Abstract
Overexpression of COX-2 has been associated with worse outcome in NSCLC. In C30203, we found that administration of the selective COX-2 inhibitor celecoxib in addition to chemotherapy in advanced NSCLC improved outcome (progression-free and overall survival, PFS, OS) in pts with moderate to high COX-2 expression by immunohistochemistry (IHC). C30801 was designed to confirm that finding. Analysis of the stable urinary metabolite of PGE-2, PGE-M, a marker of COX-2 pathway activation, was prospectively defined as a correlative study.
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