Baseline Parameters for Nonactivated Rotational Thromboelastometry Tests With and Without Heparinase in Healthy Pregnant Women at Term Gestation

Abstract

(J Clin Anesth. 2021;75:110484. doi: 10.1016/j.jclinane.2021.110484) Rotational thromboelastometry (ROTEM) provides point-of-care technology for detecting hyperfibrinolysis, a condition that can precede coagulopathy and lead to excessive bleeding with childbirth. Early awareness of the contribution of hyperfibrinolysis to postpartum hemorrhage in patients allows for targeted anti-fibrinolytic treatment that can reduce the risk of severe bleeding. This study investigates the efficacy of ROTEM for predicting the development of excessive blood loss by timely detection of hyperfibrinolysis at the earliest stages of severe hemorrhage. In addition, anticoagulation therapy is increasing in the obstetric population in response to thromboembolism as a primary cause of maternal mortality.