Baseline Optical Coherence Tomography Parameters That May Influence 6 Months Treatment Outcome of Polypoidal Choroidal Vasculopathy Eyes with Combination Therapy: A Short-Term Pilot Study.

Rituparna Ghoshal,Sharanjeet Sharanjeet-Kaur,Norliza Mohamad Fadzil,Roslin Azni Abd Aziz,Norfariza Ngah,Somnath Ghosh

doi:10.3390/ijerph18105378

Abstract

Although optical coherence tomography (OCT) parameters have assisted in the diagnosis of polypoidal choroidal vasculopathy (PCV), its potential to evaluate treatment outcomes has not been established. The purpose of this pilot study was to evaluate baseline OCT parameters that may influence treatment outcome in PCV eyes with combination therapy. In this single-centered, prospective study, patients were recruited with at least one treatment-naïve PCV eye and treated with combination therapy of intravitreal anti-vascular endothelial growth factor and photodynamic therapy. Best-corrected distance and near visual acuity (DVA and NVA), and contrast sensitivity (CS) were recorded at baseline and six months after treatment. OCT parameters were determined. Twenty-six eyes of 26 patients aged between 51 to 83 years were evaluated. In eyes that had disrupted external limiting membrane (ELM), photoreceptors inner and outer segment (IS-OS) junction at 1000 micron of fovea at baseline showed low mean visual functions after 6 months of treatment. Eyes with foveal sub-retinal fluid (SRF) and polyp at central 1000 micron of fovea at baseline showed significantly worse DVA and CS after six months. Thus, the presence of foveal SRF, foveal polyp, disrupted ELM, and IS-OS junction at baseline significantly influenced the six months’ visual outcome in PCV eyes treated with combination therapy.

Highlights

Introduction iationsOphthalmic imaging has been revolutionized by the introduction of optical coherence tomography (OCT)
1000 microns of the fovea at baseline showed significantly worse Distance visual acuity (DVA) and contrast sensitivity (CS) after six months compared to the eyes without foveal sub-retinal fluid (SRF) at baseline
There were significant differences found in the NVA and CS between eyes where both the external limiting membrane (ELM) and inner segment and outer segment (IS-OS) junction were intact, disrupted or either of them was intact at baseline

Summary

Introduction

Ophthalmic imaging has been revolutionized by the introduction of optical coherence tomography (OCT). It uses an interferometric imaging technique that produces crosssectional images by mapping reflections of low-coherence laser light from tissue based on its depth. From the time of its inception, OCT has been efficiently attempting to provide minute clinical measurements of retinal layers in an automated fashion. With OCT, imaging of a multilayer retina represents the depth of each layer with the amplitude of spectrum modulation that is proportional to the specific reflectivity of the layer. OCT plays a major role in the diagnosis and management of a broad range of retinal diseases enabling a detailed evaluation of conditions including age-related macular degeneration, central serous retinopathy, retinal vein occlusion, diabetic retinopathy, and inherited retinal diseases [1].

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