Abstract
The aim of the present study was to explore the effect of baseline beliefs about medication on therapeutic outcomes of antidepressants in inpatients with first-diagnosed depression under supervised therapeutic compliance. Ninety-seven inpatients with first-diagnosed depression were included to collect their baseline demographic data to evaluate the Hamilton depression rating scale (HAMD) scores and the beliefs about medicine questionnaire-specific (BMQ-S) scores at baseline and the end of the eight-week treatment. Additionally, we explored the relationship between inpatients’ medication beliefs and therapeutic effect of antidepressants. The inpatients were divided into remitted depression and unremitted depression groups according to outcomes at the end of the eight-week treatment. There was no significant difference in the baseline HAMD between the two groups (P > 0.050). The scores on the BMQ-S of the unremitted group were significantly lower than those of the remitted group (P < 0.001). The HAMD scores were significantly reduced in both groups after the eight-week treatment (P < 0.001). There was no significant difference in the BMQ-S scores before and after the treatment (P > 0.050). The medication beliefs of the unremitted inpatients after the treatment were still lower than those of the remitted inpatients (P < 0.001). Logistic-regression analysis showed that low BMQ-S scores at the baseline were an independent risk factor for antidepressant efficacy. Beliefs about medication at baseline may be correlated with the therapeutic efficacy in inpatients with first-diagnosed depression under supervised therapeutic compliance.
Highlights
Introduction5–12% of males and 9–26% of females will experience at least one depressive episode in their lifetime, and approximately 50% of depressed patients will experience a second depressive episode [1,2,3]
Depression is one of the most common, harmful, and burdensome mental illnesses
Pairwise comparisons showed that there was no significant difference in Hamilton depression rating scale (HAMD) scores between groups before the treatment (t = 1.559, P = 0.122) but that there was a significant difference in HAMD scores between groups after the treatment (t = −6.295, P < 0.001)
Summary
5–12% of males and 9–26% of females will experience at least one depressive episode in their lifetime, and approximately 50% of depressed patients will experience a second depressive episode [1,2,3]. Patients with two or more episodes have a 70–90% chance of recurrence of depression concomitant with poor www.aging-us.com prognosis [4, 5]. Drug treatment is the most important therapeutic approach for depression [6, 7]. Half of the patients who initially receive monotherapy show an efficacious response, and only approximately one-third of the patients obtain long-lasting relief from depression [8]. Ten to twenty percent of depressed patients who do not get relief progress to treatment-resistant depression [9, 10]
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