Abstract
It is widely used PLGA in synthesizing active drug nanoparticles due to its high biocompatibility, biodegradability, and pelletization. In this study with PLGA as the carrier, the florfenicol nanoparticles (FF-PLGA NPs) were investigated to improve water solubility and controlled drug release for achieving higher antibacterial activity. The nanoparticles were characterized by a particle analyzer and a transmission electron microscope. The size and morphology of the nanoparticles were all <200 nm. The way of drugs binding to the nanoparticles was determined by Fourier to transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). The nanoparticles with a high encapsulation rate (>80%) can achieve sustainable drug release in vitro. The addition of hydrophilic materials (2-HP-β-CD or PEG4000) to the FF-PLGA NPs improved drug solubility by about 3 and 2.5 times, respectively, and slowed down sudden release. The freeze-dried nanoparticles had high stability when stored at 4 °C. In vitro antibacterial test showed the antibacterial effects of the nanoparticle formulations on different strains were significantly improved compared with raw drugs. Hence, it is proved that PLGA as the carrier of the florfenicol nanoparticle delivery system is a new drug preparation with promising development prospects.
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