Abstract
An annulation reaction of tryptamine-derived isocyanides with hydrazonyl chlorides in the presence of bases was developed. Controlled by different bases, [1+ 2+3] annulation and [1+ 2+3]/[2 + 3] annulation cascade were realized. In the latter reaction, five new chemical bonds as well as three new heterocycles were formed in one step. It showed extremely high efficiency, relatively broad substrate scope, milder reaction conditions, good tolerance of functional groups and good chemoselectivity.
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