Abstract
AbstractActive methylene compounds such as methyl ketones, 1,3‐dicarbonyl systems and nitromethane condense under the influence of base with ω‐hydroxylactams, thereby forming α‐alkylated nitrogen heterocycles. The ease of alkylation is determined by the position of a tautomeric equilibrium between ω‐hydroxylactam and the open‐chain amide‐aldehyde, which is dependent upon the type of N‐substituent and upon the lactam ring size. Some applications for the products obtained are indicated.
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