Base‐Promoted Three‐Component Cyclization and Coupling Strategy for the Synthesis of Substituted 3‐Aryl‐5‐thio‐1,3,4‐thiadiazole‐2‐thiones

Abstract

AbstractAn effective base‐promoted cyclization and coupling strategy for the construction of substituted 3‐aryl‐5‐thio‐1,3,4‐thiadiazole‐2‐thiones from phenylhydrazines, olefins and CS2 is developed through employing CS2 as a sulfur feedstock. The reaction proceeds under mild reaction conditions in the absence of any external catalysts, transition metals and ligands. The one‐step three‐component procedure also shows the merits of simple operation, using available starting materials, wide substrate scopes, and high atom and step economy. This reaction provides facile access to substituted 3‐aryl‐5‐thio‐1,3,4‐thiadiazole‐2‐thiones, which could be used in the field of drug research.