Abstract
A t-BuOK-mediated [3 + 2] cycloaddition reaction of trifluoroacetimidoyl chlorides and active methylene isocyanides for the synthesis of 5-trifluoromethyl-imidazoles has been developed. Under mild reaction conditions, the transformation proceeds smoothly in the presence of t-BuOK to afford an array of structurally diverse 5-trifluoromethyl-imidazoles with high efficiency.
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