Base inclinations in natural and synthetic DNAs

Abstract

A sophisticated algorithm is developed to analyze flow linear dichroism data on nucleic acids for individual base inclinations. Measured absorption and linear dichroism data for synthetic AT and GC polymers and natural DNAs are analyzed. The reliability of the algorithm is tested on data for the synthetic polymers, and the results are similar to earlier, more straightforward analyse. For the first time, specific base inclinations are derived for all four individually from the linear dichroism data for natural deoxyribonucleic acids