Base Composition of the RNA of a Reovirus Variant

Abstract

A variant of reovirus 3, Dearing strain, isolated after repeated pdssage of the original Dearing virus in L cells, is similar to the parent virus in many ways. It is, however, less sensitive to specific antibodies and metabolic inhibitors, and is released from L cells to a lesser extent than the original virus. Calculated as moles per 100 moles of total base in RNA, the percentage of guanine is 20.2, adenine, 29.8, cytosine, 21.0, and uracil 29.1. These values closely approximate those reported previously for the parent virus.