Abstract
An efficient synthesis of pharmaceutically interesting 1-aryl-4-(arylethyl)piperazines by base-catalyzed hydroamination is presented. Starting from substituted aryl olefins and various N-arylpiperazines, the desired products 3 – 12 were obtained in one step under mild conditions in the presence of a catalytic amount of n-butyllithium in yields up to 99%.
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