Abstract
IntroductionBasaloid squamous cell carcinoma is a rare and aggressive variant of squamous cell carcinoma. Basaloid squamous cell carcinoma is mostly seen in the upper aerodigestive tract and has a propensity for lymph node spread and systemic metastases. Various treatment modalities have been reported, including surgical excision supplemented with radiotherapy/adjuvant chemotherapy. To the best of our knowledge, treatment of nasal basaloid squamous cell carcinoma with proton beam therapy and cisplatin has not been described in the literature.Case presentationWe report the case of a 56-year-old Japanese man with locally invasive basaloid squamous cell carcinoma in his right nasal cavity with invasion of the orbit, paranasal sinus, and buccal subcutaneous tissue. He underwent proton beam therapy concurrent with cisplatin. Acute and late side effects did not exceed grade 3. At 24-month follow up, he remains in complete remission.ConclusionProton beam therapy concurrent with cisplatin may be one choice for locally invasive basaloid squamous cell carcinoma.
Highlights
Basaloid squamous cell carcinoma is a rare and aggressive variant of squamous cell carcinoma
Case presentation: We report the case of a 56-year-old Japanese man with locally invasive basaloid squamous cell carcinoma in his right nasal cavity with invasion of the orbit, paranasal sinus, and buccal subcutaneous tissue
We report the case of a patient with locally invasive basaloid squamous cell carcinoma (BSCC) of the nasal cavity who was treated with proton beam therapy (PBT) concurrent with cisplatin (CDDP)
Summary
The histological characteristics of basaloid squamous cell carcinoma (BSCC) were first described by Wain et al in 1986 [1]. We report the case of a patient with locally invasive BSCC of the nasal cavity who was treated with proton beam therapy (PBT) concurrent with cisplatin (CDDP). Case presentation A 56-year-old Japanese man presented with a 1-month history of right nasal obstruction and ipsilateral slight pain in the buccal region. On examination, his right nasal cavity was filled with a hemorrhagic nasal polyp, and there was reddening and swelling of his skin in the right buccal region, and narrowing of the choroid fissure. The chemotherapy was single-agent, high-dose CDDP (100mg/m2) on days 1, 22, and 43 during PBT. FDG-PET after treatment showed no evidence of recurrence (Figure 4). He remains in complete remission (CR) 2 years after treatment
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