Basal cell pseudopodia in cervical intraepithelial neoplasia; progressive reduction of number with severity: A morphometric quantification

Abstract

An application of a morphometric model is used to study the stroma epithelial interface in human cervical epithelium. This model derived by Okagaki and associates estimates from two dimensional transmission electron photomicrographs the number of basal cell pseudopodia per basal cell. The investigation of the full spectrum of cervical intraepithelial neoplasia (CIN) focusing on the basal cell-stroma interface with the “multiple cell-single section” model is discussed. Significant decreases in histopathologic grades of CIN are noted in the number of pseudopodia per basal cell (N¯) and the ratio (F¯) of the area of the stems of pseudopodia to the area of the base of the basal cell.