Abstract
Increased consumption of soy and soy isoflavones is associated with a reduced risk for prostate cancer (PCa). PCa progression is characterized, in part, by a loss of luminal/basal epithelial differentiation; however, the effects of soy isoflavones on cellular differentiation in the prostate are unknown. The present study examined the effects of the soy isoflavone glycitein on cellular differentiation in prostate epithelial cells (RWPE-1, WPE1-NB14, and RWPE-2). Glycitein significantly inhibited RWPE-1 cellular proliferation at concentrations ranging from 0.4 to 50 μ M. Expression of the luminal epithelial cell marker cytokeratin 18 was not affected by glycitein treatment in the WPE1-NB14 and RWPE-2 cell lines. However, expression of cytokeratin 18 and prostate specific antigen (PSA) was decreased in the RWPE-1 cell line in response to glycitein treatment, whereas the expression of the basal epithelial cell markers p63 and cytokeratin 5 remained unchanged. These data suggest that glycitein may induce basal cell differentiation in the RWPE-1 cell line.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
