Basal cell carcinoma presenting as a perianal ulcer and treated with radiotherapy.

Abstract

Dear Editor: Basal cell carcinoma (BCC) in the perianal and genital areas accounts for <1% of all BCCs1. If the patient is unsuitable or unwilling to receive surgical treatment, topical photodynamic therapy and radiotherapy can be considered alternative treatment options2. In this report, we describe a case of BCC that presented as a perianal ulcer and showed a good response to radiotherapy. An 83-year-old man presented with an erythematous ulcer on his perianal area for 3~4 years. The skin lesion was slowly growing, but did not cause pain or bleeding. He did not report any gastrointestinal symptoms. He had a medical history of hypertension, diabetes mellitus, subarachnoid hemorrhage. On examination, a single 3.0×3.0 cm-sized, erythematous, asymptomatic ulcer with raised edges was observed on the perianal area (Fig. 1A). Under the clinical impression of Paget disease or Crohn disease, punch biopsy was performed. Histopathologically, nodular masses of basaloid cells extended into the dermis and showed a peripheral palisading pattern, which were consistent with BCC (Fig. 1B). Fig. 1 Initial clinical findings of basal cell carcinoma (BCC) in the perianal area. (A) Single, erythematous, asymptomatic ulcer with raised edge in the perianal area. (B) Histopathological findings. Nodular masses of basaloid cells extending into the dermis. ... He decided to undergo radiotherapy due to the high operative risk associated with his old age and history of subarachnoid hemorrhage. He received 3 Gy per fraction for 3 times a week for a total dose of 51 Gy over 17 fractions. At the end of radiotherapy, no acute radiogenic skin toxicities such as erythema and desquamation were noted. Two months after radiotherapy, the ulcerative lesion showed considerable clinical improvement (Fig. 1C) and still showed no aggravation after 5 month follow-up. The patient refused to undergo an additional skin biopsy; therefore, he scheduled regular follow-up visits. BCC of non-sun-exposed areas is extremely rare. Among the anogenital BCC, the pubis is the most common, followed by the perianal area, the scrotum, and the penis1. Clinical appearance ranged from erythematous papules to noduloplaques, and ulcers. According to a previous report that reviewed 51 anogenital BCCs, ulcerated lesions were seen in 15 cases (29.4%)1. Perianal ulcerative BCC may initially be misdiagnosed as a benign dermatologic or gastrointestinal disease. Perianal Paget disease, cutaneous metastasis of gastrointestinal malignancy and Crohn disease should be excluded3. Radiotherapy can be a treatment option in elderly patients and those with significant medical comorbidities4. In the present case, poor medical conditions and the location, which made it difficult for complete excision, rendered him unsuitable for surgery. However, patients treated with radiotherapy should be closely followed up because BCC treated with radiotherapy recurs more often than that treated with Mohs micrographic surgery; Rowe et al.5 reported that the 5-year recurrence rate of radiotherapy-treated disease is higher (9.8%) than that of Mohs micrographic surgery (5.6%). Also, the potential for radiogenic toxicity in the skin should not be ignored, especially when it might cause severe functional discomfort. In summary, we describe a rare case of BCC that presented as a perianal ulcer. Dermatologists should consider BCC in the differential diagnosis of a painless, ulcerated lesion on the perianal area. We also suggest considering radiotherapy in cases of BCC in the perianal area when surgical treatment is not possible.