Basal cell carcinoma of the prostate: clinicopathologic analysis of three cases and a review of the literature

Kun Chang,Xudong Yao,Jiannong Wu,Weiqiang Yao,Yuanyuan Qu,Shilin Zhang,Hailiang Zhang,Dingwei Ye,Bo Dai,Yao Zhu,Yunyi Kong

doi:10.1186/1477-7819-11-193

Abstract

BackgroundAlthough conventional adenocarcinoma accounts for the majority of prostatic carcinomas, it is important to recognize rare variants, like basal cell carcinoma (BCC), which has distinctive histopathological and biological features.Case reportWe analyzed three cases of prostatic BCC and all of them complained of acute urinary retention and digital rectal examination disclosed a stony hard prostate. However, all of them presented with low prostate-specific antigen. The diagnosis relied on transrectal ultrasound-guided needle biopsies or transurethral resection of the prostate (TURP). The microscopic findings suggested basaloid cells with large pleomorphic nuclei and scant cytoplasm, showing peripheral palisading and forming solid nests, and immunohistochemical markers like 34βE12, p63 and Ki67 staining, were positive. After active treatment, two of the patients are alive with tumor and one died five months after discharge from our hospital.

Highlights

IntroductionConventional adenocarcinoma accounts for the majority of prostatic carcinomas, it is important to recognize rare variants, like basal cell carcinoma (BCC), which has distinctive histopathological and biological features
Conventional adenocarcinoma accounts for the majority of prostatic carcinomas, it is important to recognize rare variants, like basal cell carcinoma (BCC), which has distinctive histopathological and biological features.Case report: We analyzed three cases of prostatic BCC and all of them complained of acute urinary retention and digital rectal examination disclosed a stony hard prostate
Basal cell carcinoma (BCC) of the prostate is extremely rare among prostatic carcinomas, and few cases have been reported in the literature

Summary

Introduction

Conventional adenocarcinoma accounts for the majority of prostatic carcinomas, it is important to recognize rare variants, like basal cell carcinoma (BCC), which has distinctive histopathological and biological features. Case report: We analyzed three cases of prostatic BCC and all of them complained of acute urinary retention and digital rectal examination disclosed a stony hard prostate. Two of the patients are alive with tumor and one died five months after discharge from our hospital. Basal cell carcinoma (BCC) of the prostate is extremely rare among prostatic carcinomas, and few cases have been reported in the literature. In 2007, Ali and colleagues reported 29 cases of BCC of the prostate [1], which account for the largest case series so far. We decided to treat the patient with 30.0Gy of palliative radiotherapy delivered in 10

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