Abstract
Basal cell carcinoma (BCC) is a quite ubiquitous entity in dermatology and dermatopathology, and, together with cutaneous squamous cell carcinoma (cSCC), constitutes the bulk of the socalled “nonmelanoma skin cancer” (NMSC) cases. Both BCC and cSCC arise in a similar clinical background of chronic sun damage and immunosuppression, among other risk factors. However, it is important to emphasize that BCC represents more of a locally aggressive tumor that rarely metastasizes, compared with cSCC, particularly some subtypes, which may have a higher risk of metastatic spread and even death. BCC can be classified into several variants that demonstrate different clinical behaviors, particularly in terms of local recurrence rates. We review the different facets of BCC to include up to date epidemiologic data, clinical and histopathologic presentations, as well as the latest findings on the molecular alterations driving this entity.
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