Abstract
The effects of indomethacin administration on gastric acid secretion were studied in 22 patients with arthritic diseases. Twelve patients had rheumatoid arthritis, 8 had osteoarthritis, and 1 each had Reiter's syndrome and ankylosing spondylitis. Augmented histamine tests were performed before and after a 1-month trial of the drug, administered in dosage of 75 to 100 mg per day. Repeated augmented histamine tests also were performed in 11 control subjects after a similar interval of time. No statistically significant changes in basal or histamine-stimulated gastric acid secretion were found in either the patients with arthritis or the control subjects.
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