Abstract
Background Previous studies examining barriers and willingness to participate in HIV vaccine trials have demonstrated the role of factors identified by the Health Belief Model. Barriers to cancer trials can also be understood in terms of a theoretical framework consisting of the locus of the barrier (personal vs. social) and the nature of the barrier (risk vs. cost). In this systematic review of review articles, we extend this framework to another life-threatening disease, cancer. The purpose is to improve conceptual clarity about volunteering in clinical trials by comparing and contrasting barriers in these two areas. Methods
Highlights
Previous studies examining barriers and willingness to participate in HIV vaccine trials have demonstrated the role of factors identified by the Health Belief Model
In this systematic review of review articles, we extend this framework to another life-threatening disease, cancer
Misconceptions were identified in HIV vaccine preparedness studies (VPS)
Summary
Previous studies examining barriers and willingness to participate in HIV vaccine trials have demonstrated the role of factors identified by the Health Belief Model. Barriers to cancer trials can be understood in terms of a theoretical framework consisting of the locus of the barrier (personal vs social) and the nature of the barrier (risk vs cost). In this systematic review of review articles, we extend this framework to another life-threatening disease, cancer. The purpose is to improve conceptual clarity about volunteering in clinical trials by comparing and contrasting barriers in these two areas
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