Abstract
Letters15 May 1991Barrett EsophagusN. Mullai, MD, Kulumani M. Sivarajan, MD, Gail Shiomoto, MDN. Mullai, MDSearch for more papers by this author, Kulumani M. Sivarajan, MDSearch for more papers by this author, Gail Shiomoto, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-114-10-913_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editors: Sartori and colleagues (1) reported Barrett esophagus after chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil. The hypothesis was that the drugs induced mucosal erosions and ulcerations and re-epithelialization by undifferentiated stem cells that differentiated into various cell types characteristic of Barrett esophagus.However, it was unclear why these changes were noticed only in the lower esophageal segment rather than the entire esophagus, because mucositis has no predeliction for the lower esophagus. This suggests that gastroesophageal reflux, induced either by vomiting or disturbed functioning of the lower esophageal sphincter by the chemotherapeutic drugs, is the likely culprit for the...
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