Abstract
Intracerebroventricular administration of SMS 201–995 (5 μg/rat), a somatosdtain analogue, induced barrel rotation in rats. Pretreatment with ceruletide (40 μg/100 g b.wt., IP) 3 days or 7 days prior to the injection of SMS 201–995 significantly inhibited the response rate of barrel rotation induced by SMS 201–995, but not that induced by arginine-vasopressin (1 μg/rat, ICV). The suppressive effect of ceruletide on barrel rotation could be partially countered by MK-329, a selective peripheral CCK (CCK-A) receptor antagonist. Desulfated cerulein did not affect the barrel rotation induced by SMS 201–995. These findings suggest that ceruletide specifically suppresses the barrel rotation evoked by SMS 201–995 in a long-lasting manner possibly acting through CCK-A receptor.
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