Abstract
To date, most studies investigating baroreflexes in hypertension have been performed either by recording baroreflex afferents or by denervating them. In the current issue of Hypertension , Lohmeier et al1 present data on the effects of chronic carotid sinus stimulation (CSS) in hypertensive animals. Striking differences were observed during CSS in dogs with angiotensin II (Ang II)-induced hypertension as compared with control conditions. In line with a previous study,2 baroreflex activation by CSS significantly reduced blood pressure during control. In contrast, the hypotensive effect was markedly attenuated in Ang II hypertensive dogs. This observation fits very well with today’s understanding of baroreflexes in several forms of hypertension. Remarkably, it is still not fully understood how the autonomic nervous system acts in hypertension, although the issue dates back to the very beginnings of research on cardiovascular reflexes. During that era, it …
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