Abstract
To the Editor: We wish to congratulate Sykora et al for their timely review on the potential role the arterial baroreflex plays in cerebrovascular disease outcomes.1 Although it may seem intuitive that both arterial baroreflex function and cerebral blood flow (CBF) regulation are important modulators of stroke outcome, clear and consistent evidence implicating the arterial baroreflex as an independent clinical predictor of stroke-related mortality is only emerging. The authors proffer several plausible hypotheses linking baroreflex dysfunction to the etiology of acute stroke and related clinical outcomes. Among them, the proposed “cross-linked” impairment of cerebrovascular autoregulation (CA) and altered autonomic drive as part of an underlying regulatory continuum in the context of stroke require further discussion. …
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