Abstract
Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles in health and disease. Sepsis is a life-threatening condition characterized by systemic inflammation (SI) and hemodynamic dysfunction. We hypothesized that baroreceptor denervation worsens lipopolysaccharide (LPS) induced-hemodynamic collapse and SI in conscious rats. We combined: (a) hemodynamic and thermoregulatory recordings after LPS administration at a septic-like non-lethal dose (b) analysis of the cardiovascular complexity, (c) evaluation of vascular function in mesenteric resistance vessels, and (d) measurements of inflammatory cytokines (plasma and spleen). LPS-induced drop in blood pressure was higher in sino-aortic denervated (SAD) rats. LPS-induced hemodynamic collapse was associated with SAD-dependent autonomic disbalance. LPS-induced vascular dysfunction was not affected by SAD. Surprisingly, SAD blunted LPS-induced surges of plasma and spleen cytokines. These data indicate that baroreceptor afferents are key to alleviate LPS-induced hemodynamic collapse, affecting the autonomic control of cardiovascular function, without affecting resistance blood vessels. Moreover, baroreflex modulation of the LPS-induced SI and hemodynamic collapse are not dependent of each other given that baroreceptor denervation worsened hypotension and reduced SI.
Highlights
Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles in health and disease
We investigated whether LPS-induced responses in mean arterial pressure (MAP) and heart rate (HR) were affected by the surgical removal of the arterial baroreceptors (SAD)
Considering that LPS induced a significant drop in MAP associated with autonomic dysfunction and marked changes in cardiovascular complexity, we investigated whether systemic inflammation (SI) leads to vascular damage in resistance blood vessels and if this eventual vascular dysfunction is exacerbated in rats submitted to sino-aortic denervation (SAD)
Summary
Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles in health and disease. SAD blunted LPS-induced surges of plasma and spleen cytokines These data indicate that baroreceptor afferents are key to alleviate LPS-induced hemodynamic collapse, affecting the autonomic control of cardiovascular function, without affecting resistance blood vessels. In this study we examined in an integrated and comprehensive matter the role of baroreceptor afferents integrity in LPS-induced classical inflammatory cytokines surges [in plasma and spleen – effector organ of the splenic anti-inflammatory reflex2,21], hypothermia and fever, as well as the relation of the inflammatory status with cardiovascular function in rats. We hypothesized that baroreceptor denervation worsens LPS-induced hemodynamic collapse (linked with autonomic and vascular dysfunction) and increases SI (assessed by cytokines surges in plasma and spleen) in rats
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