Baricitinib Attenuates IFN-γ and Polyinosinic:polycytidylic Acid‒Induced Mitochondrial Damage and Inflammasome Activation in Human Keratinocytes

Abstract

Alopecia areata (AA) is a common hair loss condition characterized by the acute onset of nonscarring hair loss (Shin et al., 2019). GWAS data have found several susceptibility loci involved in autoimmunity that have crucial roles in T-cell‒mediated pathways in AA pathogenesis (Betz et al., 2015; Petukhova et al., 2010). Especially, CD8+NKG2D+ T cells around the affected hair follicles contribute to the progression of inflammation, and the JAK‒signal transducer and activator of transcription (STAT) pathway plays an important role in mediating the CD8+NKG2D+T cell reaction.