Abstract
Obesity is closely associated with nonalcoholic fatty liver disease. A minority of patients with nonalcoholic fatty liver disease progress to liver cirrhosis and end-stage liver disease.1 Weight loss results in improvement of liver histology in persons with nonalcoholic fatty liver disease.2 Because weight loss can be challenging to achieve and sustain in persons with obesity, bariatric surgery is considered a feasible therapeutic option for persons with severe obesity.3 Bariatric surgery leads to improved glucose tolerance, weight loss, and improved overall mortality.4 It is less well known if bariatric surgery also reduces the incidence of liver-related outcomes. Here, we analyzed liver-related outcomes in the Swedish Obese Subjects (SOS) cohort.5.
Highlights
Bariatric Surgery Versus Standard Obesity Treatment and the Risk of Severe Liver Disease: Data From the Swedish Obese Subjects Study
During a median follow-up of 22.3 years, we verified 108 cases of severe liver disase (SLD) (2.8%): 54 in the surgery group (2.7%) versus 54 in the control group (2.8%). This difference corresponded to a hazard ratio (HR) of 0.96 after adjustment for baseline age, sex, and the aspartate aminotransferase/alanine aminotransferase ratio (95% confidence interval, 0.66–1.41)
The risk for nonalcohol-related cirrhosis in the surgery group was similar to the risk in the control population, with 38 events (2.0%) in the surgery group compared with 47 (2.4%) in the control population
Summary
Bariatric Surgery Versus Standard Obesity Treatment and the Risk of Severe Liver Disease: Data From the Swedish Obese Subjects Study. Patients were followed in national registries for incident severe liver disease, defined as diagnoses of cirrhosis or hepatocellular carcinoma until the end of 2018.
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