Bariatric surgery in obese patients with ventricular assist devices

Adrian Dasilva-Deabreu,Bader Aldeen Alhafez,Juan Francisco Loro-Ferrer,Carl J Lavie,Yuhamy Curbelo-Pena,Hector O Ventura,Stacy A Mandras

doi:10.1186/s13104-020-05221-z

Adrian Dasilva-Deabreu, Bader Aldeen Alhafez + Show 5 more

Open Access

https://doi.org/10.1186/s13104-020-05221-z

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Abstract

ObjectivesPatients with end-stage heart failure (ESHF) treated with ventricular assist devices (VADs) tend to gain weight, which may prevent them from receiving heart transplantation (HT) if their body mass index (BMI) reaches ≥ 35 kg/m2. The objective was to synthesize all cases available in the literature and describe the most important outcomes of bariatric surgery (BS) in VAD patients, including BMI trends, reaching a BMI < 35 kg/m2, listing for HT, achieving HT, myocardial recovery, and mortality. These data were obtained for an individual participant data (IPD) meta-analysis and include available IPD for every case in the scientific literature describing VAD patients undergoing BS during VAD support with documented postoperative BMI (and time of measurement) during follow-up.Data descriptionThese data include baseline, periprocedural, and long-term outcomes for the 29 patients meeting selection criteria. The composite outcome includes reaching a BMI < 35 kg/m2, listing for HT, receiving HT, and myocardial recovery, indicating significant BMI loss associated with major ESHF outcomes. As multiple centers are becoming more experienced in this field, the present data can be merged with their databases to form larger samples that will allow to perform further statistical analysis to identify outcome predictors and improve clinical protocols and outcomes.

Highlights

Only few daSilva‐deAbreu et al BMC Res Notes (2020) 13:382 large centers offer this intervention to a minority of obese patients with ventricular assist device (VAD)
This systematic review and individual participant data (IPD) meta-analysis included available IPD for every case in the scientific literature describing the outcomes of VAD patients who underwent bariatric surgery (BS) with documented postoperative body mass index (BMI) during follow-up [8]
As clinical practice and research interest in this field continues to grow, multiple centers of advanced heart failure and heart transplantation (HT) will potentially benefit from analyzing these data or merging these data with their own data to create a larger sample to perform more elaborate statistical analysis, such as regressions and subgroup analyses, to better understand the impact of BS in these obese patients with VADs and to identify predictors of major outcomes that translate into improvements in clinical practice and outcomes

Summary

Introduction

*Correspondence: adrianjdasilva@gmail.com 1 John Ochsner Heart and Vascular Institute, Ochsner Clinic Foundation, New Orleans, LA, USA Full list of author information is available at the end of the article different centers and is often higher than for HT. Few small cohort studies and case reports have shown promising results of bariatric surgery (BS) in obese patients with VADs [3–6].

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