Abstract
Background and Aims: BACKGROUND: It has been reported that a Roux-en-Y gastric bypass (RYGB) results in amelioration of the pro-oxidant status of leukocytes and metabolic profile. Nevertheless, the molecular pathways involved and how they are related with reduced cardiovascular risk are poorly understood. Hereof, AMP-activated protein kinase (AMPK) has been shown to play a role in energy homeostasis, including autophagy. Therefore, the objective of this study was to explore whether AMPK and autophagic pathways in leukocytes are implicated in their interaction with the endothelium
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