Abstract
Background and AimsGastric balloons and endoscopic sleeve gastroplasty appear to work by delaying gastric emptying. We hypothesized that pylorus-sparing antral myotomy would inhibit the antral pump inducing gastric retention and similarly result in weight loss. MethodsSingle-center pilot study to assess bariatric endoscopic antral myotomy (BEAM) via submucosal tunneling. Primary outcomes included feasibility, safety, and efficacy at 6 and 12 months. Secondary outcomes included changes in gastric emptying rate and GCSI score. ResultsSix subjects underwent successful BEAM. One required needle decompression, and another developed pulmonary embolism, treated without sequela. At 6 and 12 months, patients achieved 9.1±8.9% and 12.2±7.1% TWL (P<0.0005). Gastric emptying rate was delayed by 36.6% in those with ≥10% TWL. GCSI increased significantly at 12 months, particularly early satiety. ConclusionThis pilot study suggests BEAM is feasible and appears to induce delayed gastric emptying that is associated with significant weight loss, without symptoms of gastroparesis.
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