BaO–Fe2O3 containing bioactive glasses: A potential candidate for cancer hyperthermia

Abstract

A series of BaO–Fe2O3 bioactive glasses synthesized with the sol-gel technique. In this research, the magnetic properties of prepared bioactive glass were examined to study the potential application of these materials in cancer hyperthermia. To this goal, physical, morphological and, magnetic behavior of synthesized magnetic bioactive glass, were examined. Scanning Electron Microscopy, X-ray Powder Diffraction, and also Transmission Electron Microscopy used to characterize the composition and morphology of the glass nanoparticles. The size of glass particles studied by Laser Particle Size Analyzer (LPSA). Thermal analysis was used to determine the final heat treatment temperature via Differential Thermal Analysis (DTA). To evaluate the magnetic properties of synthesized glasses, Vibrating Sample Magnetometer, and Calorimetric test used.The results of this research showed that BaO–Fe2O3 addition in the glass structure affects the magnetic behavior of the bioactive glass. VSM (Vibrating Sample Magnetometer) and calorimetric test results prove that the magnetic behavior of the glasses increases with the increase of magnetic content. Results showed that BG1010 and BG0515 generate enough heat for the application of these materials in cancer hyperthermia. Considering Cytocompatibility, Bioactivity, and magnetic properties, it seems the BG1010 sample is the best candidate to use in hyperthermia treatments. Finally, this study proves that the prepared bioactive glasses with magnetic content are good candidates in cancer hyperthermia applications.