Abstract
Insulin resistance induced by chronic inflammation enhances metabolic dysfunction in obesity. The aim of this study was to investigate the effects of Bangle (Zingiber purpureum) extract (Ba) on insulin resistance and inflammation in the gastrocnemius muscle (GM) of high-fat diet (HFD)-fed SAMP8 mice. Male mice were divided into three groups: HFD, HFD + 1%Ba, and + 2%Ba. The SAMP8 control (Con) and SAMR1 control (Rcon) were fed a low-fat diet. At week 26, plasma blood parameters, macrophage infiltration, levels of expression and phosphorylation of Akt, mTOR, and AMPK were examined. The levels of plasma glucose and insulin in the HFD group were significantly higher than those in the Con group. Conversely, these levels in the HFD + 2%Ba group were significantly lower than those in the HFD group. Treatment with 2% Ba suppressed the degree of macrophage infiltration induced by HFD in the GMs. The levels of phosphorylated Akt and mTOR were decreased and the levels of phosphorylated AMPK in the HFD + 2%Ba group were increased compared with those in the HFD group. Ba may attenuate HFD-induced insulin resistance and inflammation by modulating the AMPK/Akt/mTOR pathway in the GMs of HFD-fed young SAMP8 mice.
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