BANCR: a novel oncogenic long non-coding RNA in human cancers.

Yifan Zou,Fuyou Zhang,Dan Yu,Huizhong Xiao,Kewang Luo,Yincong Chen,Jianfa Li

doi:10.18632/oncotarget.22031

Abstract

Long non-coding RNAs account for large proportion of non-coding transcripts in human genomes. Though they lack of open reading framework and cannot encode protein, they can control endogenous gene expression though regulating cell life activities. They serve as transcriptional modulator, posttranscriptional processor, chromatin remodeler and splicing regulator during the process of gene modification. Moreover, long non-coding RNAs were regarded as potential tumor markers for cancer diagnosis and prognosis. BANCR was identified as a cancer-promoting long non-coding RNA in melanoma tissues. Since then, increasing studies about BANCR in cancer progression were reported. BANCR was dysregulated in various cancers including melanoma, colorectal cancer, retinoblastoma, lung carcinoma and hepatocellular carcinoma, and increased BANCR expression cause poor prognosis and shorter survival rate of cancer patients. Furthermore, the functions and mechanisms of BANCR in cancer cells have been clarified. Here, we focus on the current research on the role of BANCR in the clinical management, progression and molecular mechanisms in human cancer.

Highlights

Cancer is a major public health problem worldwide and the second leading cause of death in the United States
Most of transcripts can not encode protein, which are named as non-coding RNAs [5]. ncRNAs are generally divided by length into two categories: small ncRNAs, transcripts that are lesser than 200 bp in length; and long ncRNAs that are greater than 200 bp [6]
The results suggested that BRAFactivated non-coding RNA (BANCR) may function as a novel target for Lung carcinoma (LC) chemotherapy in the future, and deeper insight of BANCR will help us to understand the oncogenesis of LC

Summary

Introduction

BANCR was identified as a cancer-promoting long non-coding RNA in melanoma tissues. Many studies have reported that lncRNAs participate in various aspects of cell biology and potentially contribute to tumor development through stimulating or inhibiting cell proliferation, apoptosis, differentiation, invasion and metastasis [8,9,10,11,12]. BANCR is responsible for proliferation, migration, invasion and apoptosis of cancer cells [38,39,40,41]. Flockhart et al [40] and McCarthy N [43] originally identified a previously unstudied but widely expressed lncRNA BANCR as playing a potentially functional role in melanoma cell migration by RNA sequencing.

Results

Conclusion