Abstract
The work of the German geographer and naturalist Alexander von Humboldt, Political Essay on the Kingdom of New Spain (1811), allows us to undertake a review of smallpox epidemics that affected the population of New Spain during the XVIII century and the arrival and development subsequent vaccine against the disease in those territories. On the other hand, since that humboldtiana cosmogony, it is also invited to reflect on the significance of the Royal Expedition and the figure of its director, Francisco Balmis, compared with the Humboldt himself and his experience in New Spain.
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