Abstract
The first application of the ball-milling technology in solvent-free asymmetric organocatalysis is reported. The authors have chosen the quinidine-mediated desymmetrization of meso-anhydrides as a test reaction. The resulting hemiesters are obtained in high yields and with moderate enantioselectivities. Under the same ball-milling conditions, a proline-catalyzed aldol reaction has been conducted, giving anti-aldol products with moderate to high diastereo-, as well as with good to excellent enantioselectivities after short reaction times. In both cases, the results compare well with those of similar reactions performed in solution at ambient temperature. A comparative study using conventional magnetic stirring could demonstrate the beneficial effect of ball milling.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
