Abstract
Introduction of an α-hydroxyacid moiety in position 5 of the imidazole ring within the imidazolyl biphenyl sulfonyl urea series significantly increased AT 2 binding. Structure activity relationship around this moiety is described and gave rise to balanced AII inhibitors with nanomolar affinity on both AT 1 and AT 2 receptors and with an AT 2 AT 1 ratio of between 0.4 and 3.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
