Abstract

In this paper, a mathematical model which consists of system of differential equations with piecewise constant argument is constructed to describe tumor-immune system interaction. The system is based on the tumor growth model constructed by Kuznetsov et all. A solution of the system with piecewise constant arguments leads to a system of difference equations. Using Schur-Cohn criterion and a Lyapunov function, sufficient conditions are obtained for the local and global asymptotic stability of a positive equilibrium point of the system of difference equations. Neimark-Sacker bifurcations analysis shows that stable limit cycle occurs at the bifurcation point, thus resulting oscillations for tumor and immune system.

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