Abstract
IntroductionTo know the prevalence of primary resistance in chronic hepatitis B naïve patients is essential to decide on the need of routine laboratory testing. Patients and methodsThe genetic sequence of the HBV polymerase from 105naïve patients was analysed. ResultsrtV173L, a lamivudine compensatory mutation, was detected in two patients (1.9%), rtI233V in one patient, and another one carried the sG145R vaccine escape mutation. ConclusionOur study shows that studying HBV resistance in naïve patients should not be recommended in the routine laboratory setting, for the time being
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