Abstract
Abstract Baicalin is a flavonoid that has an influence on molecular processes. It possesses anticancer, anti-inflammatory, antiviral, antioxidative, and antithrombotic properties. It was found that baicalein treatment attenuated the damage of the mammary gland induced by LPS, suppressed the activity of myeloperoxidase, TNFα, and IL-1β in mice with mastitis. The aim of the study was a pilot analysis of baicalin tolerability after intramammary (IMM) administration and its impact on somatic cell count (SCC) after multiple IMM treatment on dairy cows with clinical mastitis. Moreover, the determination of baicalin in milk was performed by the sensitive ultra-high performance liquid chromatography with tandem mass spectrometry. The pharmacokinetic analyses were performed using Phoenix® WinNonlin® 6.4 and ThothPro v 4.1 software. Twelve dairy cows with clinical mastitis were selected for this study. The pharmacodynamic endpoint was SCC level and the clinical investigation was also carried out. Baseline SCC analysis was performed every 24 h among all cows three days before the first dose (B1–B3). After the baseline monitoring, 8 days of treatment (T1–T8) was performed and 8 days within recovery period SCC level was observed (R1–R8). Starting from T1 to T8, a decrease of SCC in relation to baseline was characterized by a declining trend. The presented results confirm the effect of baicalin on the reduction of SCC in mastitis in dairy cows after this therapy. The current study has shown that baicalin accumulation was not confirmed.
Highlights
Based on previous studies it appears that baicalin may have activity against the causative agents of mastitis
These studies indicated that baicalin possesses anti-inflammatory, antiviral, antioxidative, anticancer, and antithrombotic properties (Ma et al, 2005; LiWeber, 2009; Li et al, 2011; Guo et al, 2013, 2014; He et al, 2015)
It was found that baicalin has antioxidant effects on bovine mammary cells (Perruchot et al, 2019)
Summary
The aim of the study was a pilot analysis of baicalin tolerability after intramammary (IMM) administration and its impact on somatic cell count (SCC) after multiple IMM treatment on dairy cows with clinical mastitis. The aim of this study was the analysis of the possible impact of baicalin on somatic cell count (SCC) after multiple intramammary (IMM) treatments of dairy cows with mastitis
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