Abstract
Background/aim Bone tumor is one of the major causes of tissue bone loss, particularly after performing surgical excision operation to bone lesion that needs to be replaced by biomaterials and ensure a complete filling of tissue-loss spaces. The purpose of our study was to produce a nanofiber-based bone graft scaffold to fill the gaps resulted from bone cancer treatment and also capable of carrying functional molecules that can play a major role in preventing further cancer growth at the targeted bone tissue.Materials and methods Electrospinning method was used in order to produce nanofibers from different kinds of polymers; Hyaluronic acid (HA), Polyethylene oxide (PEO) and Polyvinyl alcohol (PVA) blended with different concentrations of herbal antibiotic and anti cancer flavonoid molecules called Baicalein (BE). The morphological and chemical structures of scaffold samples were studied using Scanning Electron Microscope (SEM), Fourier Transform Infrared-spectroscopy (FT-IR) and Surface-enhanced Raman spectroscopy (SERS) Analysis.Results The results showed production of homogenous nanofibers-based scaffold (diameter between 80 nm and 470 nm) that contains the polymers used in the spinning process and the entrapped Baicalein molecules within the nanofiber structure.ConclusionIt was concluded that successful formation of bone tissue mimicking scaffold can be achieved by using Electrospinning method that produces nonwoven nanofibers and at the same time can hold functional anticancer agent such as Baicalein, which may allow using these types of scaffold in bone cancer treatment procedures.
Highlights
Incidence of local recurrence of osteosarcoma and giant cell tumor of the bone after joint salvage surgery is 10%– 15% and 0%–65% [1], respectively
The results showed production of homogenous nanofibers-based scaffold that contains the polymers used in the spinning process and the entrapped Baicalein molecules within the nanofiber structure
It was concluded that successful formation of bone tissue mimicking scaffold can be achieved by using Electrospinning method that produces nonwoven nanofibers and at the same time can hold functional anticancer agent such as Baicalein, which may allow using these types of scaffold in bone cancer treatment procedures
Summary
Incidence of local recurrence of osteosarcoma and giant cell tumor of the bone after joint salvage surgery is 10%– 15% and 0%–65% [1], respectively. Electrospinning system consists of polymer solution that puts in a high electrical field. The high voltage of applied electrical field will play a role in deforming the spherical shape of solution droplet, which possesses resistance forces like surface tension and solution viscosity. This process gives the droplet a conical shape called Taylor cone. Loading nanofibers with active ingredients, like bone morphogenic protein (BMP7) to improve osteoinductivity [9] and cis-diamminedi-iodoplatinum as anticancer agent [19], has been established
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