Abstract
BackgroundBACTIBASE is an integrated open-access database designed for the characterization of bacterial antimicrobial peptides, commonly known as bacteriocins.DescriptionFor its second release, BACTIBASE has been expanded and equipped with additional functions aimed at both casual and power users. The number of entries has been increased by 44% and includes data collected from published literature as well as high-throughput datasets. The database provides a manually curated annotation of bacteriocin sequences. Improvements brought to BACTIBASE include incorporation of various tools for bacteriocin analysis, such as homology search, multiple sequence alignments, Hidden Markov Models, molecular modelling and retrieval through our taxonomy Browser.ConclusionThe provided features should make BACTIBASE a useful tool in food preservation or food safety applications and could have implications for the development of new drugs for medical use. BACTIBASE is available at http://bactibase.pfba-lab-tun.org.
Highlights
BACTIBASE is an integrated open-access database designed for the characterization of bacterial antimicrobial peptides, commonly known as bacteriocins.Description: For its second release, BACTIBASE has been expanded and equipped with additional functions aimed at both casual and power users
We have previously developed and described a database (BACTIBASE) that contains calculated or predicted physicochemical properties of bacteriocins produced by both Gram-positive and Gram-negative bacteria [8]
While lantibiotics are the class I of bacteriocins, the Collection of Anti-Microbial Peptides (CAMP) database lists them as a distinct family from bacteriocins
Summary
The dramatic rise in antibiotic-resistant pathogens has renewed efforts to identify, develop and redesign antibiotics. We have previously developed and described a database (BACTIBASE) that contains calculated or predicted physicochemical properties of bacteriocins produced by both Gram-positive and Gram-negative bacteria [8]. These characteristics may serve as a physicochemical fingerprint for each group. With our new domain name, users may link directly to records using their BACTIBASE ID in the format http://bactibase.pfba-lab-tun.org/bacteriocinsview.php?id=BAC059, which will allow links to be maintained even if the bacteriocin data changes. Forum The forum section is provided to allow anyone to exchange information or ask questions regarding bacteriocins
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