Abstract
Bacteriostatic and Bactericidal Mechanism of Novel Compound Isolated from Ethyl Acetate Stem Bark Extract of Spondias mombin Using Biomarker Repressor LexA gene on Escherichia coli and Bacillus subtilis
Highlights
Spondias mombin Linn is a small tree that grows up to 30 m high and 1.5 m in height, moderately buttressed; bark thick, corky, deeply fissured, slash pale pink, darkening rapidly, branches low, branchlets glabrous; leaves pinnate, leaflets 5-8 opposite pairs with a terminal leaflet
It was observed that at 30 minutes, the mechanism of action is bacteriostatic action on the test organism (B. subtilis), but an SOS regulum was activated by B. subtilis at 180 minutes, to resuscitate the dying cell of B. subtilis
The purpose of the research work is to determine the mechanism of action of compound A1 (Epigallocatechin, Epicatechin and Stigmasterol Phytosterol (Synergy), A3(Aspidofractinine-3-methanol) and F3(Terephthalic acid, dodecyl 2-ethylhexyl ester) with two selected micro-organism
Summary
Spondias mombin Linn is a small tree that grows up to 30 m high and 1.5 m in height, moderately buttressed; bark thick, corky, deeply fissured, slash pale pink, darkening rapidly, branches low, branchlets glabrous; leaves pinnate, leaflets 5-8 opposite pairs with a terminal leaflet. It belongs to the family Anacardiaceae and the fruits have a sharp, acid taste [1]. The stem bark decoction is used in the treatment of severe cough and used for diarrhea, dysentery, haemorrhoids and a treatment for gonorrhoea and leucorrhea [2]. A decoction of the root is used as purgative [8,9]
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