Abstract
The relationship between structure and activity in bacteriostasis was compared to the relationship between structure and reactivity in metal chelate formation for various kojic acid analogs. The metal chelating property with Cu2+ and Cd2+ was closely related to the acid dissociation constant. Since structure-activity analyses showed that the neutral molecule is the active form, and since the pKA value as the electronic parameter is related to the activity only for the neutral molecule but not for the ionized form, it was postulated that metal chelate formation is not significant for manifestation of the bacteriostatic activity of this series of compounds. This postulation was confirmed in experiments under conditions in which the metal was depleted or excessive. The bacteriostatic activity of kojic acid analogs against such bacteria as S. aureus 209P, E. coli K–12 and Ps. fluorescens was neither retarded nor enhanced.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
