Abstract
Aeromonas species often cause disease in farmed fish and are responsible for causing significant economic losses worldwide. Although vaccination is the ideal method to prevent infectious diseases, there are still very few vaccines commercially available in the aquaculture field. Currently, aquaculture production relies heavily on antibiotics, contributing to the global issue of the emergence of antimicrobial-resistant bacteria and resistance genes. Therefore, it is essential to develop effective alternatives to antibiotics to reduce their use in aquaculture systems. Bacteriophage (or phage) therapy is a promising approach to control pathogenic bacteria in farmed fish that requires a heavy understanding of certain factors such as the selection of phages, the multiplicity of infection that produces the best bacterial inactivation, bacterial resistance, safety, the host’s immune response, administration route, phage stability and influence. This review focuses on the need to advance phage therapy research in aquaculture, its efficiency as an antimicrobial strategy and the critical aspects to successfully apply this therapy to control Aeromonas infection in fish.
Highlights
Increasing global production to offset progressive worldwide reductions in the amount and quality of natural seafood populations has contributed to making aquaculture one of the fastest-growing productive agricultural sectors
These authors confirmed these results by Fourier-Transform Infrared Spectroscopy (FTIR), where the spectra obtained from the fourth and fifth streak-plating colonies were similar to the ones from phage-sensitive control colonies, suggesting that these colonies are more similar to the control phage-sensitive bacteria than the colonies from streak-plating steps one, two and three [290]
In 2016, we reported the impact of phage AS-A on natural bacterial communities of an aquaculture system and bacterial community associated with fish intestinal tract [51]
Summary
Increasing global production to offset progressive worldwide reductions in the amount and quality of natural seafood populations has contributed to making aquaculture one of the fastest-growing productive agricultural sectors. Phages are bacteria-infecting viruses that are abundantly present in the environment and essential in controlling bacterial populations in natural systems [2,32] Their potential use in agriculture, aquaculture, veterinary, food safety and medicine is being studied worldwide [2,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49]. The use of phages to inactivate pathogenic bacteria in farmed fish has gained momentum, mainly due to their inherent low toxicity [32] This growing trend seems to show an increased interest in industrial applications of phages in aquaculture. This review highlights and discusses the potential that phage therapy has to control Aeromonas in fish, the main preventive measures used and the aspects that need to be considered when applying phage therapy in aquaculture
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
