Abstract
Background: The present study evaluates the efficacy of bacteriophage therapy for urinary tract infection (UTI) in rats. Methods: UTI was established by inoculating Escherichia coli (100μl) at a concentration of 1.5×108CFU/ml per urethra via a cannula in different groups of rats. For treatment, phage cocktails (200μl) were administered at varying concentrations of 1×108PFU/ml, 1×107PFU/ml and 1×106PFU/ml. Results: The two doses of phage cocktail at the first two concentrations resulted in the cure of UTI. However, the lowest concentration of the phage cocktailwarranted more doses to eradicate the causative bacteria. Conclusion: The quantity, frequency and safety ofdoses could be optimized ina rodent model using the urethral route.
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