Abstract
Increased intestinal permeability and translocation of gut microbiota from the intestinal lumen to the systemic circulation predispose patients to various diseases and may be one of the main triggers thereof. The role of microbiota in increased intestinal permeability is under intensive investigation. Here, we studied alterations in the host and increased intestinal permeability as a direct effect of treatment with a bacteriophage cocktail. After 10 days of challenge, the rats showed weight loss, messy hair, and decreased activity. Additionally, they displayed a significantly elevated lactulose:mannitol ratio and the level of circulating immune complexes. To our knowledge, this study demonstrates for the first time that increased intestinal permeability may be induced by bacteriophages that affect the microbiota.Electronic supplementary materialThe online version of this article (doi:10.1186/s13099-016-0109-1) contains supplementary material, which is available to authorized users.
Highlights
The human microbiota is comprised of bacteria, fungi, and viruses including bacteriophages, and is a very complex ecosystem that is in dynamic stability with each of its components and the host organism
We measured serum circulating immune complexes (CIC) to evaluate possible systemic inflammatory response to the alterations caused by bacteriophage infection
This study demonstrated that increased intestinal permeability may be induced by bacteriophages that affect the microbiota
Summary
Background The human microbiota is comprised of bacteria, fungi, and viruses including bacteriophages, and is a very complex ecosystem that is in dynamic stability with each of its components and the host organism. We evaluated the effect of primary lesions of the microbiota on intestinal permeability. The objective of this study was to assess the effect of microbiota treatment with bacteriophages on the intestinal permeability in vivo.
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