Abstract
BackgroundDiabetic foot infection (DFI) is a serious complication of diabetes mellitus and identification of the causative bacteria is an essential step in selecting the appropriate antibiotic therapy. This study aimed to evaluate the bacterial pattern and antibiotic susceptibility of the bacteria causing DFI in Lampung Province in Indonesia.MethodsThis study is a retrospective study reviewing the medical records of DFI patients admitted to the Dr Hi Abdul Moeloek Regional General Hospital in 2017–2019. DFI patients with complete medical record data were included in this study. Demographic, clinical, laboratory, wound culture and antibiotic susceptibility data were collected from the medical records using a short structural chart. The data obtained then reviewed.ResultsIn this study, 131 DFI patients met the study criteria and were included. Based on the wound culture results, Gram-negative bacteria were obtained in 112 (85.5%) subjects with Enterobacter spp. as the predominant bacteria. Gram-positive bacteria were found in 19 (14.5%) subjects with Staphylococcus spp. as the predominant bacteria. Gram-negative bacteria found in this study showed high susceptibility to amikacin, meropenem and sulbactam/cefoperazone. Meanwhile, the Gram-positive bacteria showed high susceptibility to meropenem, sulbactam/cefoperazone and amikacin.ConclusionThe findings of the study revealed Enterobacter spp. as the most predominant bacteria causing DFI in the studied population. The highest antibiotic susceptibility was seen for amikacin, meropenem and sulbactam/cefoperazone.
Highlights
Diabetes mellitus is one of the leading causes of morbidity and mortality in the world
Diabetes mellitus is an endocrine disorder that can result in various complications, including diabetic foot infection (DFI)
Grampositive bacteria were mostly susceptible to meropenem (92.9%), sulbactam/cefoperazone (86.7%) and amikacin (80%)
Summary
Diabetes mellitus is one of the leading causes of morbidity and mortality in the world. To this day, an estimated 463 million adults live with diabetes worldwide. An estimated 463 million adults live with diabetes worldwide This figure is projected to grow to up to 700 million by 2045 [1]. Diabetes mellitus is an endocrine disorder that can result in various complications, including diabetic foot infection (DFI). Diabetic foot infection (DFI) is a serious complication of diabetes mellitus and identification of the causative bacteria is an essential step in selecting the appropriate antibiotic therapy.
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