Bacteriological profile and antibiotic susceptibility pattern (antibiogram) of urinary tract infections in paediatric patients

Abstract

Background: Urinary tract infection (UTI) is one of the most common paediatric infections.It may cause permanent kidney damage. So the knowledge on common causative organism will help in initiation of treatment of UTI. Aim: The aim of this study was to find out the causative agents of urinary tract infections and their antibiotic sensitivity pattern in paediatric patients in S.S.G Hospital, Baroda. Material &Methods: A study was conducted at S.S.G hospital,Barodafrom January 2012 to June 2012. Total 1263 samples collected from paediatric patients suspected of having UTI. The bacterial agents which caused UTI were isolated, characterised & identified using standard microbiological tests. Antibiogramof all the isolates were performed by the disc-diffusion (Modified-Kirby Bauer technique) according to CLSI guidelines using Amikacin, Gentamicin, Cefotaxime, Chloramphenicol, Nitrofurantoin, Piperacillin, Piperacillin+Tazobactum, Ofloxacin, Norfloxacin, Ampicillin+Sulbactum. Results: The prevalence of UTI among paediatric patient was 29.78%. Escherichiacoli (38.42%)were the most frequent cause of UTIfollowed by Klebsiella spp. (23.89%), Acinetobacter spp.(11.33%). Maximum isolates of urinary samples were sensitive to Amikacin(63.79%) and Piperacillin+Tazobactum(63.05%). Conclusion: The prevalence of UTI amongst paediatric patients was high and Escherichia coli were the most frequent etiologic agent followed by Klebsiella species being the second most common. Clinician should prefer Amikacin for treatment of UTI in paediatric patients. In case of Amikacin resistance, Piperacillin+Tazobactum can be used.